this is a condition in which serum find out the specific pathologically altered immunoglobulins (cryoglobulins), which is able at temperatures below 37 degrees to precipitate and form deposits on the walls of blood vessels, causing a vasculitis.
The disease is always the result of diseases, in particular viral infections. As already noted, crioglobuline by nature very close to antibodies, meaning that the body produces for protection against pathogens and viruses. They are able to recognize, bind and eliminate the source of infection.
Cryoglobulinemia most often caused by viruses hepatitis b and C, herpes, HIV, cytomegalovirus and Epstein-Barr (causative agent of mononucleosis). Of bacterial infections it is possible to allocate syphilis, endocarditis and abscesses.
There are factors that can trigger onset of the disease
- prolonged exposure to the cold
- rapid dehydration
- hormonal failure.
This disease has no age limit (people from 20 to 70 years). It is believed that with age increases the risk of cryoglobulinemia. But most often it affects women after the age of 40.
At the moment doctors have not allocated the characteristic symptoms of this disease. Most people (90% of cases) there is the appearance of purpura and rashes, especially on the lower extremities and buttocks. 70% of patients complain of joint pain (mostly hands and feet). Recorded as a manifestation of Raynaud’s syndrome, when the disease and symptoms reminiscent of lupus or rheumatoid arthritis.
Cryoglobulinemia is the most dangerous for the kidneys because there are concentrated the smallest capillary vessels. Their blockage can lead to thrombosis and further irreversible pathology.
To date, a scheme of treatment of the disease there. Because cryoglobulinemia is the consequence of another disease, first of all, the prescribed treatment is subject to the primary disease, i.e. eliminate the cause of the blood cryoglobulins.