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How does an enterically coated pill make it through say your liver?

I have always wondered about this, I mean if a capsule survives until it gets into the colon, do you have a hole in each of your organs that has to close after the pill goes through it? Hahahaha. Thank you so much to anyone who knows.



An enterically coated pill is coated so that it will not give you a tummy ache in your stomach. It is then digested by enzymes in the small intestine where the ingredients are absorbed. They travel through the blood stream to all the organs.


I don’t think any pill will make it past the acid bath it gets in your stomach – the enteric coating prevents it from being absorbed in the esophagus but it will be dissolved in the stomach and the chemicals will enter the bloodstream through the walls of the small intestine.


Most enteric coatings work by presenting a surface that is stable at the highly acidic pH found in the stomach, but breaks down rapidly at a less acidic (relatively more basic) pH. For example, they will not dissolve in the acidic juices of the stomach (pH ~3), but they will in the higher pH (above pH 5.5) environment present in the small intestine.


Enteric coated pills, are covered by a substance (there are several of them) that will prevent such pill from dissolving in the acid environment of the stomach (Ph or acidity fluctuates between 3,5-4), and then the coat will be dissolved in the small intestine by the action of the bile, pancretatic enzymes, and alkaline environment brought upon by the mucus of the gut, with several enzymes…
When the tablet dissolves in such alkaline medium, the contents are liberated, and absorption is then possible by the veins located in the wall, as well as lymphatic vessels,,,the venis will collect all the absorbed substances, to the porta vein, that will carry the drug to the liver cells (hepatocytes) qhere its modified, or distributed to other tissues.at the end, the effect will take place in the whole of the body…distributed by the bloodstream…
No enteric coated pill will remain coated until it reaches the colon,,,,there is no possble nor technical way to do that…on the other hand, such property, would be worthless…