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Tubulointerstitial nephritis

Tubulointerstitial nephritis

non-specific kidney disease caused by the presence of inflammatory process in intermediate renal tissue. In this disease, reduced kidney function, leading to kidney failure. The disease has two forms acute and chronic.


In 95% of cases of acute tubulointerstitial nephritis is the result of infectious diseases, allergies to medications (especially antibiotics), poisoning by toxins.

The reason of development of chronic form of the disease may be the presence of systemic diseases (infections, impaired metabolism, hypertension, etc.). and drug toxicity caused by prolonged intake of drugs, among which in the first place are analgesics.

The prevalence

Since in clinical practice rarely establish this diagnosis, it is still not available accurate data about the extent of its prevalence. According to literary sources, over the past decade, cases of this disease among the adult population.


In acute manifestation of the disease, patients complain of flank pain and lower back, fever, skin rashes. Deterioration of health, the symptoms of acute renal failure high blood pressure edema volume reduction and change in the color of urine.

The symptoms in the early stages of chronic tubulointerstitial nephritis, as a rule, are absent. Blood pressure normal or slightly increased, edema is usually not observed. The symptoms appear only when under the influence of the inflammatory process of the renal function deteriorates significantly, resulting in chronic renal failure.


Treatment of patients with a diagnosis of tubulointerstitial nephritis is preferably carried out in a hospital. However, the main efforts directed at addressing the causes of kidney failure. Recommended bed rest, sparing diet with restriction of salt and fluid intake in sufficient quantity.

If the patient is assigned adequate therapy, it does not provoke the disease drugs. In this case, his body positively responds to treatment, and has all the chances to fully restore kidney function.