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Addison s Disease

A painful condition of the adrenal cortex that occurs when bilateral lesions, leading to reduced secretion of hormones or their complete cessation, is called

Addison’s disease

. The disease is widely known as bronze disease, yet it is called the adrenal insufficiency.

There is a disease with a large lesion of the adrenal tissue, more than 90% of the surface. Mainly cause of the disease is an autoimmune process (in which the human immune system itself attacks the adrenal cortex), the frequency of occurrence of Addison’s disease is preceded by tuberculosis.

Chronic adrenal insufficiency syndrome manifests itself in many inherited diseases.


Causes of Addison’s disease

  • autoimmune injury of tissue of the adrenal glands (where your own immune system attacks the body)
  • the disease occurs in tuberculosis of the adrenal glands
  • when removing the adrenal gland
  • may be a consequence of a long hormonal therapy
  • fungal diseases (histoplasmosis, coccidioidomycosis, blastomycosis)
  • in tumors
  • when

  • when



Symptoms of Addison disease pronounced increase in ACTH (adrenocorticotropic hormone level) and increase the content of alpha-melanocytestimulating the hormone that is responsible for darkening of the skin and mucous membranes. A characteristic feature of Addison’s disease, the development of the disease the skin start to darken, in this regard, in the people this disease called bronze disease.

In secondary insufficiency of the adrenal cortex develops failure of the pituitary gland (a gland in the brain). In primary insufficiency, the skin does not darken.

One or symptomatology of the disease depends on the duration and shape of the disease, manifestations of disease depend on the insufficient secretion of hormones of the adrenal gland. In primary insufficiency there may be a darkening of the mucous membranes and skin, but this symptom is years ahead of all the others. In Addison’s disease-Barmera due to autoimmune destruction possible and the simultaneous presence of


One of the symptoms of Addison’s disease is weakness. Also, there is fatigue, weight loss, reduction of appetite. Lowered blood pressure, frequent dizziness, appears poor tolerance of cold temperatures due to the decrease in blood pressure.

The gastrointestinal tract also suffers from. Vomiting, nausea, possible diarrhea or constipation. When adrenal insufficiency is sometimes observed, and mental disorders such as depression or psychosis.

Also enhanced olfactory and auditory receptors. Sometimes the patient can really want salty foods. Appear adrenal crises. At the extreme there is a sudden deficiency of hormones after the increase in demand or reduction uroregion against the existing Addison’s disease.

Causes of adrenal crisis

  • (this can be a variety of physical and emotional stress for the human body)

  • bilateral hemorrhage into the adrenal glands
  • embolism of the arteries or


  • removal of the adrenal gland.

Adrenal insufficiency, symptoms (in severe disease)

  • decreases blood pressure
  • start abdominal pain
  • nausea
  • dizziness.


Test is conducted by an endocrinologist, he diagnoses the functionality of the adrenal glands.


The treatment of the disease of Adisson is to conduct therapy and adherence to special diets. Therapy

  • use hydrocortisone. Also used fludrocortisone. Drugs used for replacement of adrenal hormones
  • prescribed hydrocortisone every afternoon
  • fludrocortisone 1 time a day. If blood pressure rises, then the dose a little lower. In acute disease, the dose is double to improve the health of the patient.

If carried out surgery of the patient, if necessary, the dose of hormonal drugs raise or lower. If a person suffers from liver failure or other liver disease, the dose of drugs reduced.

Diet you must eat a sufficient amount of all the minerals, vitamins, fats, proteins, carbohydrates. In particular, it is necessary to consume vitamins C and B. Table salt is also recommended for use, therefore, its daily rate was increased to 20 g In the diet of the patient reduce the consumption of foods such as peas, dried fruits, chocolate, mushrooms, coffee, potatoes, beans, cocoa. Fish, vegetables or meat should be consumed only in cooked form. Assign fractional power mode.