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Goodpasture Syndrome

  1. Reasons
  2. Symptoms
  3. Diagnosis
  4. Treatment

Goodpasture Syndrome

immunolocalisation disease of the small blood vessels of the kidneys and the lungs. This disease can occur at any age, but most often the syndrome occurs in young men. Goodpasture’s syndrome in children, adolescents and elderly people is rare and is found after a differential diagnosis.

Forms of goodpasture’s syndrome

The rate of development of symptoms there are two forms of the disease

  • rapid progression

    • dominated by renal and pulmonary symptoms
    • death occurs after 1112 months as a result of pulmonary hemorrhage or renal failure.
  • slow for

    • periods of progression alternating with periods of complete absence of symptoms
    • if treatment is started promptly, the lifespan can range from 2 to 12 years.


Causes of goodpasture’s syndrome

  • the cause of the syndrome is unknown, but revealed a direct relationship with bacterial and viral infections, and some medications immunosuppressive, anti-inflammatory, cytostatic
  • goodpasture’s syndrome can develop under the influence of chemical and physical environmental factors (organic solvents, the effect of hydrocarbons, steam paints, gasoline), on the background of cancer
  • regular use of cocaine also described cases of this disease
  • autoimmune cause of the disease is the most common, it is production of antibodies to specific structures of the lungs and kidneys.


Symptoms of goodpasture’s syndrome manifested in the following

  • the main feature of the disease is a combination of symptoms

    with hemoptysis (sign of the collapse of lung tissue)

  • appear peripheral edema (swelling of the face, belly, legs)
  • marked anemia (anemia)
  • progressive chest pain, cough, shortness of breath
  • malaise, weakness, weight loss
  • periodically there is an increase in body temperature
  • inflammation of the eye
  • decrease in urine
  • the appearance of blood in the urine
  • blood pressure rises from 14090 mm Hg. art. and above.


  • the analysis of the anamnesis of disease and complaints which symptoms appeared, and when, did the patient to the doctor, as the symptoms changed over time, what tests and treatment were conducted and what the results
  • analysis of life history at which the specified data on the presence of harmful habits, chronic diseases and diseases transferred earlier
  • analysis of family history, in which it is specified whether met a similar disease in relatives (e.g. rapidly progressive glomerulonephritis)
  • common blood test will detect any signs of inflammation in the body (a significant increase in the level of erythrocyte sedimentation rate, increased level of white blood cells, high content of reticulocytes)
  • biochemical analysis of blood can detect elevated levels of residual nitrogen and reduction of serum iron
  • a urine test that will detect the following changes

    • proteinuria in which urine protein is detected
    • hematuria in which the urine is found in the blood
    • cylindruria
    • as a rule, in the sediment of the urine erythrocytes, leukocytes, erythrocyte and granular casts.
  • sputum, which is found siderophile and red blood cells in large numbers
  • a study of all functions of external respiration, which will reveal its decline
  • examination of the lungs (x-ray) will reveal pulmonary infiltrates in the basal region that covers the middle and lower parts of the lungs and progressing of the cloud-symmetrical bilateral infiltrates
  • the reaction immunofluorescence (RIF) is a method of studying tissue samples of lung and kidney, taken with a biopsy based on the illumination of the special substances in ultraviolet rays, which binds to an antigen (any substance that the human body regards as foreign or potentially dangerous, and then begins to actively produce protective proteins) of the unknown microbe.
  • manifestation in the blood-specific proteins that have a negative impact on the structure of the kidney
  • consultation physician pulmonologist.


In the treatment of goodpasture syndrome include the following

  • early appointment of large doses of immunosuppressants and corticosteroids
  • plasmapheresis for immediate removal of antibodies circulating in the blood (this is a procedure in which the patient is taken blood from which plasma is removed, and then the blood cells are returned back to blood vessels)
  • hemodialysis, which is the cleansing and filtering of blood outside the body
  • symptomatic therapy that includes the drug of iron and repeated blood transfusions.


If a patient has goodpasture syndrome, to date, all available treatments are unable to provide complete cure, or prevent worsening

  • in many ways, the prognosis of the syndrome remains dire
  • renal failure acute
  • recurring pulmonary hemorrhage
  • fatal.


  • the rejection of all sorts of bad habits
  • timely and complete treatment of various infectious diseases and colds
  • the appearance of hemoptysis or the appearance of blood in the urine should immediately consult a doctor.